HCID 21830680, compound → HCID 21830678, compound

Participants

Reaction Steps

A solution of 1-(3'-acetylbiphenyl-4-yl)-5-(3-pyridyl)pent- 1-yn-3-ol (0.7 g) in absolute ethanol (20 ml) was hydrogenated for 24 hours at 1.2 atmospheres using palladium on carbon (10%, 0.1 g) as catalyst. The reaction mixture was filtered through Celite® and the residue washed with ethanol. The combined filtrate and washings were concentrated under reduced pressure. The residue was purified by column chromatography over silica eluting with dichloromethane:methanol (97:3) to give the title compound as a colourless oil (0.25 g).

Provenance & Evidence