Ethanol → HCID 21830642, compound

HRID 1600960Notes

Reaction equation

HRID 1600960 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)=[CH:4][CH:3]=1.C(O)C.[OH-].[Na+].Cl[CH2:20][CH:21]([OH:30])[CH2:22][CH2:23][C:24]1[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=1>O>[N:26]1[CH:27]=[CH:28][CH:29]=[C:24]([CH2:23][CH2:22][CH:21]([OH:30])[CH2:20][O:1][C:2]2[CH:3]=[CH:4][C:5]([C:8]3[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=3)=[CH:6][CH:7]=2)[CH:25]=1

Participants

6

Reactant 4

HCID 702EthanolHCID 14798Sodium HydroxideHCID 153040Phenol, 4-(3-pyridinyl)-HCID 22465338HCID 22465338, compound

Product 1

HCID 21830642HCID 21830642, compoundYield 38.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Prepared according to the method as described in Example 24b) from 3-(4-hydroxyphenyl)pyridine (1.68 g), ethanol (30 ml), sodium hydroxide (0.393 g), water (10 ml) and (±)-α-(chloromethyl)-3-pyridinepropanol (0.91 g, Example 24a)) to give the title compound as a pale yellow solid (0.6 g).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-a22a157eccd442b7a0fc39a21fc1519c
Source dataset
uspto-grants-1999_11
Patent number
US05977105

Reaction notes

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