Toluene → HCID 21830740, compound

Participants

Reaction Steps

Prepared according to the method described in Example 33a) from toluene (7.5 ml), (±)-1-(2-acetyl-4-bromophenoxy)-4-(3-pyridyl)-2-butanol (0.134 g), benzeneboronic acid (0.07 g), aqueous sodium carbonate (2 M, 1 ml), ethanol (2.5 ml) and tetrakis(triphenylphosphine)palladium(0) (0.02 g) with heating at reflux for 3 hours. After work up the residue was purified by column chromatography over silica eluting with ethanol:dichloromethane (5:95) to give the title compound as an oil (0.070 g).

Provenance & Evidence