Sodium Hydroxide → HCID 67596932, compound

Participants

Reaction Steps

Prepared according to the method described in Example 24b) from 3-cyclopentyloxy-4-methoxyphenol (0.835 g), ethanol (10 ml), aqueous sodium hydroxide (2 M, 2.5 ml) and (±)-α-(chloromethyl)-3-pyridinepropanol (0.760 g, Example 24a) to give the title compound as a yellow oil. This was purified by column chromatography over silica eluting with dichloromethane:ethanol and further purified by preparative normal-phase HPLC on a Dynamax™ Silica column with dichloromethane:ethanol (19:1). The purified material was then converted to the oxalate salt by treatment with excess oxalic acid in diethyl ether to give the title compound as a white solid (0.197 g).

Provenance & Evidence