HCID 53696716, compound → HCID 54036729, compound

Participants

Reaction Steps

Solid (2R)-1-(3'-(Benzyloxy)biphenyl-4-yloxy)-4-(3-pyridyl)-2-butanol (0.88 g, Example 93c) was dissolved in dry ethanol (150 ml) and hydrogenolysed for 24 hours at 3 atmospheres pressure over a palladium on carbon catalyst (10%, 0.09 g). The reaction mixture was filtered through Celite® and the residue washed with ethanol. The combined filtrate and washings were concentrated under reduced pressure and the residue obtained purified by column chromatography over silica eluting with dichloromethane:methanol (98:2) to give the title compound as a white solid (0.52 g).

Provenance & Evidence