Tetrabutylammonium Fluoride → HCID 54365189, compound

Participants

Reaction Steps

(2R)-2-(tert-Butyldimethylsilyloxy)-4-(3-pyridyl)-1-(3-trifluoromethylbiphenyl-4-yloxy)butane (0.8 g, ~67% pure) was dissolved in tetrahydrofuran (10 ml) and tetrabutylammonium fluoride (0.84 g) was added. The reaction was stirred at ambient temperature for 1 hour and was then poured into brine and extracted with ether. The combined organic extracts were dried over anhydrous magnesium sulfate, filtered, concentrated under reduced pressure. The residue obtained was purified by reverse phase HPLC to give the title compound as a white solid (0.13 g).

Provenance & Evidence