HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethenyl-3-methylbenzene → HCID 54230854, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethenyl-3-methylbenzene | HCID 7529 | — |
| Reactant | Tri-o-tolylphosphine | HCID 80271 | — |
| Reactant | Ethyl acetate hexane | HCID 21226206 | — |
| Reactant | HCID 54306446 | HCID 54306446 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 54230854 | HCID 54230854 | — |
Reaction Steps
A solution of 5-bromo-2-trifluoroacetoxy-1,2,3,4-tetrahydroisoquinoline (616 mg, 2 mmol), 3-vinyltoluene (330 mg, 2.5 mmol), tri-o-tolylphosphine (50 mg) and palladium acetate (20 mg) in triethylamine (1 mL) were heated in a pressure bomb at 100° C. for 8 h. Column chromatography of the dark mixture (silica gel; hexane/EtOAc 40:1 then 20:1) afforded the title compound. FAB ms (m+1) 346.18
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05977134 |
| Source dataset | uspto-grants-1999_11 |
| ORD ID | ord-7ae93ee29eb6411287671c0169a760e5 |
| Source note | uspto-grants-1999_11 |