Benzenemethanamine, 3-chloro- → HCID 54319558, compound

HRID 1601032Notes

Reaction equation

HRID 1601032 reaction equation
[CH3:1][C:2]([O:5][C:6]([N:8]1[C@H:17]([C:18](O)=[O:19])[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])[CH3:3].[Cl:21][C:22]1[CH:23]=[C:24]([CH:27]=[CH:28][CH:29]=1)[CH2:25][NH2:26]>>[Cl:21][C:22]1[CH:23]=[C:24]([CH:27]=[CH:28][CH:29]=1)[CH2:25][NH:26][C:18]([C@@H:17]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH2:9][N:8]1[C:6]([O:5][C:2]([CH3:3])([CH3:4])[CH3:1])=[O:7])=[O:19]

Participants

3

Reactant 2

HCID 77802Benzenemethanamine, 3-chloro-HCID 664088(3S)-2-((tert-butoxy)carbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Product 1

HCID 54319558HCID 54319558, compound

Procedure

N-Boc-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Bachem) was coupled with 3-chlorobenzylamine using standard peptide coupling procedures to give the title compound.

Sources & evidence

ORD record
ord-48aaf4f12eb840b4a5b4c1538b7c2c08
Source dataset
uspto-grants-1999_11
Patent number
US05977134

Reaction notes

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