2-Methylphenyl boronic acid → HCID 21831056, compound

HRID 1601039Notes

Reaction equation

HRID 1601039 reaction equation
Br[C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[CH:5][N:6]2[CH2:11][C:12]1[N:16]([CH2:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]#[N:25])=[CH:20][CH:19]=2)[CH:15]=[N:14][CH:13]=1.[CH3:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1B(O)O>>[CH3:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[CH:5][N:6]2[CH2:11][C:12]1[N:16]([CH2:17][C:18]2[CH:19]=[CH:20][C:21]([C:24]#[N:25])=[CH:22][CH:23]=2)[CH:15]=[N:14][CH:13]=1

Participants

3

Reactant 2

HCID 27332672-Methylphenyl boronic acidHCID 21831028HCID 21831028, compound

Product 1

HCID 21831056HCID 21831056, compound

Procedure

Following the procedure described for Example 21, Step 3, 4-bromo-1-(1-(4-cyanobenzyl)-5-imidazolylmethyl)indole (Example 28) was coupled with 2-methylphenyl boronic acid to give the title compound.

Sources & evidence

ORD record
ord-135b8e6147904240a6a1f76e8441fe74
Source dataset
uspto-grants-1999_11
Patent number
US05977134

Reaction notes

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