Hydrochloric Acid → 1-(4-Cyanobenzyl)imidazole-5-acetic acid

Participants

Reaction Steps

A solution of [1-(4-cyanobenzyl)-lH-imidazol-5-yl]acetic acid methyl ester (4.44 g, 17.4 mmol ) in THF (100 mL) and 1 M lithium hydroxide (17.4 mL, 17.4 mmol) was stirred at room temperature for 18 h. 1 M HCl (17.4 mL) was added and the THF was removed by evaporation in vacuo. The aqueous solution was lyophilized to afford the title compound containing lithium chloride as a white solid.

Provenance & Evidence