Potassium Hydroxide → HCID 178419380, compound

HRID 1601046Notes

Reaction equation

HRID 1601046 reaction equation
Cl.Cl.[NH2:3][CH2:4][CH2:5][C:6]1[N:10]=[CH:9][NH:8][CH:7]=1.[OH-].[K+].[Br:13][C:14]1[CH:15]=[C:16]([CH:19]=[CH:20][CH:21]=1)[CH:17]=O>CCO>[Br:13][C:14]1[CH:15]=[C:16]([CH:17]2[C:7]3[NH:8][CH:9]=[N:10][C:6]=3[CH2:5][CH2:4][NH:3]2)[CH:19]=[CH:20][CH:21]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 765833-BromobenzaldehydeHCID 178478691HCID 178478691, compound

Product 1

HCID 178419380HCID 178419380, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
77 °C

Procedure

Histamine dihydrochloride (3.68 g, 0.02 mol), KOH (3.36 g, 0.06 mol), and 3-bromobenzaldehyde were dissolved in H2 0 (250 mL) and EtOH(100 mL). The reaction mixture was heated for 24 h at 77° C. open to the atmosphere. The resulting white precipitate was filtered and dried under vacuum at 40° C. to give the title compound.

Workup

  1. filtrationThe resulting white precipitate was filtered
  2. customdried under vacuum at 40° C.

Sources & evidence

ORD record
ord-a9e411fe7d4a4365a3e6a85c236a0d69
Source dataset
uspto-grants-1999_11
Patent number
US05977134

Reaction notes

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