Trifluoroacetic acid → HCID 21831035, compound

Participants

Reaction Steps

To a solution of 4-(3-bromophenyl)-1-[3-(4-cyanobenzyl)-3H-imidazol-4-ylmethyl]-1,4,6,7-tetrahydroimidazo[4,5-c]pyridine-5-carboxylic acid tert-butyl ester (0.045 g, 0.078 mmol) dissolved in CH2Cl2 (5 mL) was added TFA (1 mL) and the reaction mixture was stirred at room temperature under Ar for 2h. The solution was concentrated in vacuo and purified using reverse phase liquid chromatography (95/5 -5/95 H2O/CH3CN with 0.1% TFA over 60 min, flow rate =65 mL/min) to yield the title compound.

Provenance & Evidence