反应详情

Di-tert-butyliminodicarboxylate (4.35 g, 20.0 mmol) was added to a suspension of sodium hydride (0.48 g, 20.0 mmol) in anhydrous DMF (30 mL) at RT. After 30 minutes, a solution of t-butyl 3-bromomethyl-4-nitrobenzoate (6.3 g, 20 mmol) in DMF (15 mL) was added rapidly dropwise. After 16 h, the solvent was evaporated and the residue partitioned between EtOAc (200 mL) and water (40 mL). The organic layer was extracted with water (3×50 mL) and brine (40 mL) and dried finally over Na2SO4. Removal of solvent gave the crude product which was purified on flash chromatography (15:85; EtOAc:Hexane) to give the title compound (81.5%): MS (ES) m/e 453 (M+H)+ ; 1H NMR (400 MHz, CDCl3) δ 7.97-8.10 (m, 3H), 5.16 (s, 2H), 1.62 (s, 9H), 1.49 (s, 18H).

1. waitAfter 16 h
2. customthe solvent was evaporated
3. customthe residue partitioned between EtOAc (200 mL) and water (40 mL)
4. extractionThe organic layer was extracted with water (3×50 mL) and brine (40 mL)
5. dry with materialdried finally over Na2SO4
6. customRemoval of solvent
7. customgave the crude product which
8. customwas purified on flash chromatography (15:85; EtOAc:Hexane)