反应详情

A solution of tert-butyl 3-[[bis-(t-butoxycarbonyl)]amino]methyl-4-nitrobenzoate (4.2 g, 9.3 mmol) in ethanol (150 mL) was hydrogenated at 40 psi in the presence of 10% Pd on C (0.40 g). After 30 minutes, catalyst was filtered and solvent removed to give the title compound in essentially quantitative yield: MS (ES) m/e 423 (M+H)+ ; 1H NMR (400 MHz, CDCl3) δ 7.82 (s, 1H), 7.71 (d, J=8.4 Hz, 1H), 6.56 (d, J=8.4 Hz, 1H), 4.92 (br s, 2H), 4.68 (s, 2H), 1.62 (s, 9H), 1.49 (s, 18H).

1. filtrationcatalyst was filtered
2. customsolvent removed