Ammonium Hydroxide → 1H-Indole-2-carboxamide

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl indole-2-carboxylate (5 g, 26.5 mmol) and ammonium hydroxide (30 mL) was heated at 80° C. in a sealed glass vessel overnight. The reaction was cooled and the title compound (3.06 g, 73%) was collected by filtration as a colorless solid: 1H NMR (400 MHz, DMSO-d6) δ 7.95 (br, 1H), 7.61 (d, 1H), 7.41 (d, 1H), 7.36 (br, 1H), 7.12, (t, 1H), 7.01 (t, 1H).

Provenance & Evidence