HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2,3-Dihydro-1H-indole-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Methyl indoline-2-carboxylate | HCID 2794655 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2,3-Dihydro-1H-indole-2-carboxamide | HCID 13937810 | 85% |
Reaction Steps
Gaseous NH3 was bubbled into a solution of methyl (±)-indoline-2-carboxylate (4.3 g, 24.2 mmol) in methanol (50 mL) at RT for 30 min. The reaction was stirred for 18 h, then was filtered to afford the title compound (3.35 g 85%) as a colorless solid: MS (ES) m/e 163.0 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05977101 |
| Source dataset | uspto-grants-1999_11 |
| ORD ID | ord-bb54d9bbb43f4187b24382d845ce13de |
| Source note | uspto-grants-1999_11 |