Acetonitrile--water (1/1) → HCID 53794639, compound

Participants

Reaction Steps

A mixture of benzyl 4-[2-[[[1-[(benzimidazol-2-yl)methyl]benzimidazol-2-yl]methyl]methylamino]acetyl]phenoxyacetate (0.08 g, 0.18 mmol) and 5% Pd/C (0.11 g) in MeOH (15 m L) was shaken on a Parr apparatus under H2 (41 psi) for 1 h. The mixture was filtered through a bed of Celite®, and the filter pad was washed with glacial AcOH and MeOH. The filtrate was concentrated to give the crude product (0.07 g). Preparative HPLC (Hamilton PRP-1® column, step gradient, 10-30% CH3CN/H2O-0.1% TFA) afforded the title compound: MS (ES) m/e 484.2 [M+H]+. Anal. Calcd for C27H25N5O4.3 C2HF3O2 : C, 48.01; H, 3.42 N, 8.48. Found: C, 48.40; H, 3.72; N, 8.77.

Provenance & Evidence