HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → tert-butyl2-methyl-1H-benzo[d]imidazole-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Methylbenzimidazole | HCID 11984 | — |
| Reactant | Di-tert-butyl dicarbonate | HCID 90495 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | tert-butyl2-methyl-1H-benzo[d]imidazole-1-carboxylate | HCID 11183867 | 100% |
Reaction Steps
A mixture of 2-methylbenzimidazole (1.5 g, 11.35 mmole), Et3N (1.66 mL, 11.92 mmole), DMAP (0.20 g, 1.6 mmole), and (BOC)2O (2.60 g, 11.92 mmole) in anhydrous CH2Cl2 (15 mL) was stirred at RT for 24 hr, then was concentrated. The residue was taken up in H2O, stirred, and filtered to afford the title compound (2.63 g, 100%) as a colorless solid: mp 71-72° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05977101 |
| Source dataset | uspto-grants-1999_11 |
| ORD ID | ord-60034c79c38d422194d7452195f25780 |
| Source note | uspto-grants-1999_11 |