HCID 21831180, compound → HCID 21831175, compound

Participants

Reaction Steps

A mixture of 5.0 g (21 mmol) of 2-(2-methylphenoxymethyl)-3-nitropyridine (Example 3.d) and 100 ml of N-methylmorpholine was hydrogenated at room temperature (approximately 25° C.) and an H2 pressure of approximately 1.1 bar in the presence of 1 g of 5% platinum/charcoal (51% water; manufactured by Degussa). The hydrogen uptake ceased after approximately 90 minutes. The catalyst was removed by filtration through active charcoal. The resulting solution was freed from solvent under reduced pressure, and the residue obtained was treated with approximately 50 ml of petroleum ether. This gave 7.8 g (90%) of the title compound as a white solid. The solvent was removed under reduced pressure ("high vacuum"), and the residue obtained was washed using hexane. This gave 4.5 g (94%) of the title compound as a white solid.

Provenance & Evidence