Methyl chloroformate → HCID 21831182, compound

Participants

Reaction Conditions

Reaction Steps

2.1 g (22 mmol) of methyl chloroformate were added dropwise at -10° C. to a mixture of 4.3 g (mmol) of N-[2-(2-methylphenoxymethyl)pyridin-3-yl]hydroxylamine (Example 3.e), 3.3 g (39 mmol) of NaHCO3 (solid) and 50 ml of methylene chloride. After the reaction mixture had been stirred for 4 hours at room temperature (approximately 25° C.), it was washed with water, dried and freed from solvent under reduced pressure. The residue was purified by column chromatography (cyclohexane/ethyl acetate). This gave 0.6 g (10%) of the title compound as a yellow oil.

Provenance & Evidence