tert-Butanol → HCID 86754742, compound

At 70° C., a mixture of 1.2 g (9.2 mmol) of 2-methoxyimino-3-hydroxyiminobutane and 25 ml of tert-butanol was treated with 1.03 g (9.2 mmol) of potassium tert-butylate, and the mixture was stirred for 1 hour. The reaction mixture was freed from solvent under reduced pressure at approximately 40° C. The residue was introduced into 15 ml of dimethyl sulfoxide, and 2 g (9.2 mmol) of methyl N-methoxy-N-(2-chloropyridin-3-yl)carbamate, dissolved in 3 ml of dimethyl sulfoxide, were added at 50° C. The mixture was stirred for 2 hours at 100° C., and the reaction mixture was transferred to approximately 150 g of ice and extracted with tert-butyl methyl ether. The organic phases were combined, washed with water, dried, and the solvent was removed, under reduced pressure. The resulting residue was purified by column chromatography over silica gel using cyclohexane/ethyl acetate (2:1). This gave 470 mg (17%) of the title compound as a brown solid.

1. customwas freed from solvent under reduced pressure at approximately 40° C
2. additionwere added at 50° C
3. stirringThe mixture was stirred for 2 hours at 100° C.
4. extractionextracted with tert-butyl methyl ether
5. washwashed with water
6. customdried
7. customthe solvent was removed, under reduced pressure
8. customThe resulting residue was purified by column chromatography over silica gel

ORD record

ord-5ea317d1f0cd4843b748351b08e48f8f

Source dataset

uspto-grants-1999_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05977146