Ethanol → 1-{[(3-Aminoquinolin-4-yl)amino]methyl}cyclobutanol

HRID 160124Notes

Reaction equation

HRID 160124 reaction equation
[CH3:21][CH2:22][OH:23].[N+:1]([O-:2])(=[O:3])[c:4]1[cH:5][n:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[c:13]1[NH:14][CH2:15][C:16]1([OH:20])[CH2:17][CH2:18][CH2:19]1.[OH-:24].[OH-:26].[Pd+2:25]>>[NH2:1][c:4]1[cH:5][n:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[c:13]1[NH:14][CH2:15][C:16]1([OH:20])[CH2:17][CH2:18][CH2:19]1

Participants

5

Reactant 4

HCID 702EthanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 574578111-{[(3-Nitroquinolin-4-yl)amino]methyl}cyclobutanol

Product 1

HCID 574578121-{[(3-Aminoquinolin-4-yl)amino]methyl}cyclobutanol

Sources & evidence

ORD record
ord-7ac97702c0e44869864bd29c163ed587
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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