HCID 54491600, compound → HCID 53964867, compound

Participants

Reaction Steps

Pyridinium chlorochromate (15.28 g, 70.9 mmol) was added to a solution of phenyl-carbamic acid 4-hydroxy-4-phenyl-butyl ester (13.48 g, 4.73 mmol), prepared in the previous step, in 300 ml of methylene chloride and the mixture stirred at room temperature for 2.5 hours. The reaction was poured onto 700 g of a silica gel (230-400 mesh) column made with methylene chloride. Eluting with 0.5%-1.5% ethyl acetate-methylene chloride gave phenyl-carbamic acid 4-oxo-4-phenyl-butyl ester (10.98 g, 82%) as a white solid, mp 121-123° C.

Provenance & Evidence