1-((2-(2,4-Difluorophenyl)-3-methyloxiran-2-yl)methyl)-1H-1,2,4-triazole, (2R-cis)- → HCID 178462382, compound

HRID 1601342Notes

Reaction equation

HRID 1601342 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@@:9]1([CH2:13][N:14]2[CH:18]=[N:17][CH:16]=[N:15]2)[C@H:11]([CH3:12])[O:10]1.C([S:22][C@H:23]1[CH2:28][CH2:27][C@H:26](/[CH:29]=[CH:30]/[C:31]2[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][CH:32]=2)[CH2:25][CH2:24]1)(=O)C>>[Cl:37][C:34]1[CH:33]=[CH:32][C:31](/[CH:30]=[CH:29]/[C@H:26]2[CH2:27][CH2:28][C@H:23]([S:22][C@H:11]([CH3:12])[C@:9]([C:3]3[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=3[F:1])([OH:10])[CH2:13][N:14]3[CH:18]=[N:17][CH:16]=[N:15]3)[CH2:24][CH2:25]2)=[CH:36][CH:35]=1

Participants

3

Reactant 2

HCID 101311911-((2-(2,4-Difluorophenyl)-3-methyloxiran-2-yl)methyl)-1H-1,2,4-triazole, (2R-cis)-HCID 178477146HCID 178477146, compound

Product 1

HCID 178462382HCID 178462382, compoundYield 31%

Procedure

Reaction and treatment were carried out in the same manner as in Example 1 using (2R,3S)-2-(2,4-difluorophenyl)-3-methyl-2-[(1H-1,2,4-triazol-1-yl)methyl]oxirane and trans-1-(acetylthio)-4-[(E)-2-(4-chlorophenyl)vinyl]cyclohexane to obtain the desired compound having a melting point of 64 to 66° C. in a yield of 31%.

Workup

  1. customReaction and treatment

Sources & evidence

ORD record
ord-6faf43cff897414792fdae0cffd310b6
Source dataset
uspto-grants-1999_11
Patent number
US05977152

Reaction notes

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