(2E,4E)-5-[4-(Trifluoromethyl)phenyl]-2,4-pentadienal → HCID 178460848, compound

HRID 1601348Notes

Reaction equation

HRID 1601348 reaction equation
[OH:1][CH2:2][CH:3]([S:6][C:7]([CH3:27])([CH3:26])[C:8]([C:16]1[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=1)([OH:15])[CH2:9][N:10]1[CH:14]=[N:13][CH:12]=[N:11]1)[CH2:4][OH:5].FC(F)(F)[C:30]1[CH:35]=[CH:34][C:33](/[CH:36]=[CH:37]/[CH:38]=[CH:39]/[CH:40]=O)=[CH:32][CH:31]=1>>[CH3:26][C:7]([S:6][C@@H:3]1[CH2:4][O:5][C@@H:40](/[CH:39]=[CH:38]/[CH:37]=[CH:36]/[C:33]2[CH:32]=[CH:31][CH:30]=[CH:35][C:34]=2[C:22]([F:25])([F:24])[F:23])[O:1][CH2:2]1)([CH3:27])[C:8]([C:16]1[CH:17]=[CH:18][C:19]([C:22]([F:24])([F:23])[F:25])=[CH:20][CH:21]=1)([OH:15])[CH2:9][N:10]1[CH:14]=[N:13][CH:12]=[N:11]1

Participants

3

Reactant 2

HCID 10609261(2E,4E)-5-[4-(Trifluoromethyl)phenyl]-2,4-pentadienalHCID 18363280(RS)-3-[(1,3-dihydroxy-2-propyl)thio]-3-methyl-2-[4-(trifluoromethyl)phenyl]-1-(1H-1,2,4-triazol-1-yl)-2-butanol

Product 1

HCID 178460848HCID 178460848, compound

Procedure

Reaction was carried out in the same manner as in Example 4 using (RS)-3-[(1,3-dihydroxy-2-propyl)thio]-3-methyl-2-[4-(trifluoromethyl)phenyl]-1-(1H-1,2,4-triazol-1-yl)-2-butanol as described in Reference example 55 and (2E,4E)-5-[4-(trifluoromethyl)phenyl]-2,4-pentadienal as described in Reference example 25 to obtain the title compound, a major product as a colorless foam.

Workup

  1. customReaction

Sources & evidence

ORD record
ord-87b558fe301d4b64a09e0801b5fe6ea9
Source dataset
uspto-grants-1999_11
Patent number
US05977152

Reaction notes

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