HCID 54253937, compound → HCID 178462414, compound

HRID 1601349Notes

Reaction equation

HRID 1601349 reaction equation
[CH3:1][C@H:2]1[O:4][C@@H:3]1[CH2:5][N:6]1[CH:10]=[N:9][CH:8]=[N:7]1.C([S:14][C@@H:15]1[CH2:20][O:19][C@@H:18](/[CH:21]=[CH:22]/[CH:23]=[CH:24]/[C:25]2[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][CH:26]=2)[O:17][CH2:16]1)(=O)C>>[N:6]1([CH2:5][C@@:3]([C:25]2[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][CH:26]=2)([OH:4])[C@H:2]([S:14][C@@H:15]2[CH2:16][O:17][C@@H:18](/[CH:21]=[CH:22]/[CH:23]=[CH:24]/[C:25]3[CH:26]=[CH:27][C:28]([C:31]([F:32])([F:33])[F:34])=[CH:29][CH:30]=3)[O:19][CH2:20]2)[CH3:1])[CH:10]=[N:9][CH:8]=[N:7]1

Participants

3

Reactant 2

HCID 54253937HCID 54253937, compoundHCID 178477155HCID 178477155, compound

Product 1

HCID 178462414HCID 178462414, compoundYield 71%

Procedure

Reaction was carried out in the same manner as in Example 1 using (2R*,3R*)-3-methyl-2-[(1H-1,2,4-triazol-1-yl)methyl]oxirane and trans-5-(acetylthio)-2-[(1E,3E)-4-[4-(trifluoromethyl)phenyl]-1,3-butadien-1-yl]-1,3-dioxane to obtain the title compound as an oil in a yield of 71%.

Workup

  1. customReaction

Sources & evidence

ORD record
ord-3e0cc3ab8d3f49f785aca5b297ecef63
Source dataset
uspto-grants-1999_11
Patent number
US05977152

Reaction notes

Loading…