反应详情

温度

50 °C

Combine 1-benzyl-4-(pyrid-3-yl)-4-cyanopiperidine hydrochloric acid salt (10.0 g, 28 mmol), sodium hydroxide (7.6 g, 190 mmol), and water (2 mL) in ethylene glycol (120 mL). Heat to reflux. After 15 hours, evaporate in vacuo to give a residue. Combine the residue with methanol (20 mL) and ethanol (20 mL) and stir to give a solid. Filter to remove the solid. Add ethanol (50 mL) to the filtrate and stir for 1 hour to give a second solid. Remove the second solid by filtration and acidify the filtrate with aqueous 12M hydrochloric acid solution. Evaporate the acidified filtrate in vacuo to give a residue. Combine the residue and dichloromethane. Extract with water. Adjust the pH of the aqueous layer to 7 using sodium bicarbonate. Evaporate the aqueous layer in vacuo to give a residues combine the residue and ethanol and again evaporate in vacuo to give a residue. Combine the residue with methanol and heat to about 50° C. to give a slurryb. Filter the slurry add acetone (30 mL) to the filtrate to give a solid. Collect the solid by filtration, rinse with acetone, and dry to give 1-benzyl-4-(pyrid-3-yl)-piperidine-4-carboxylic acid.

1. temperatureHeat to reflux
2. customevaporate in vacuo
3. customto give a residue
4. customto give a solid
5. filtrationFilter
6. customto remove the solid
7. stirringAdd ethanol (50 mL) to the filtrate and stir for 1 hour
8. customto give a second solid
9. customRemove the second solid
10. filtrationby filtration
11. customEvaporate the acidified filtrate in vacuo
12. customto give a residue
13. extractionExtract with water
14. customEvaporate the aqueous layer in vacuo
15. customto give a residues
16. customagain evaporate in vacuo
17. customto give a residue
18. customto give a slurryb
19. filtrationFilter the slurry
20. additionadd acetone (30 mL) to the filtrate
21. customto give a solid
22. customCollect the solid
23. filtrationby filtration
24. washrinse with acetone
25. customdry