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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1601693Generated: October 26, 2026

Glycolic Acid → 2-(Hydroxymethyl)-Alpha,Alpha-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol

https://huagongshe.com/reaction/1601693

Reaction equation

Participants

RoleNameHCIDCharge
ReactantGlycolic AcidHCID 757—
Reactant1-((3-Aminoquinolin-4-yl)amino)-2-methylpropan-2-olHCID 14986941—
Product2-(Hydroxymethyl)-Alpha,Alpha-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanolHCID 22672658—

Reaction Steps

Using the general method of Example 24, 3-amino-4-(2-hydroxy-2-methylpropylamino)quinoline (45 g, 0.19 mol) was reacted with glycolic acid to provide 35.7 g of the desired product as a tan solid. The structure was confirmed by nuclear magnetic resonance spectroscopy.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05977366
Source datasetuspto-grants-1999_11
ORD IDord-b1589872024c41f78dca4f4d6dd2f062
Source noteuspto-grants-1999_11