反应详情

4-Chloro-α,α-dimethyl-2-ethoxymethyl-1H-imidazo[4,5-c]quinoline-1-ethanol (1.0 g, 3 mmol, Example 100) and 7% methanolic ammonia (30 mL) were placed in a steel pressure vessel at about 150-160° C. for 6 hours. The vessel was cooled to below room temperature and the reaction solution removed and treated with methanolic potassium hydroxide. The solution was then evaporated to a low volume and diluted with water. The resulting precipitate was collected, washed with water and dried to provide 0.7 g of the crude product as a solid. The crude product was recrystallized from a mixture of ethyl acetate and methanol to provide a colorless solid.

1. temperatureThe vessel was cooled to below room temperature
2. customthe reaction solution removed
3. additiontreated with methanolic potassium hydroxide
4. customThe solution was then evaporated to a low volume
5. additiondiluted with water
6. customThe resulting precipitate was collected
7. washwashed with water
8. customdried