3-Methoxypropanoyl chloride → HCID 15224451, compound

HRID 1601704Notes

Reaction equation

HRID 1601704 reaction equation
[NH2:1][C:2]1[C:3]([Cl:17])=[N:4][C:5]2[C:10]([C:11]=1[NH:12][CH2:13][CH2:14][CH2:15][CH3:16])=[CH:9][CH:8]=[CH:7][CH:6]=2.[CH3:18][O:19][CH2:20][CH2:21][C:22](Cl)=[O:23]>>[CH2:13]([NH:12][C:11]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[C:3]([Cl:17])[C:2]=1[NH:1][C:22](=[O:23])[CH2:21][CH2:20][O:19][CH3:18])[CH2:14][CH2:15][CH3:16]

Participants

3

Reactant 2

HCID 27597283-Methoxypropanoyl chlorideHCID 15224450HCID 15224450, compound

Product 1

HCID 15224451HCID 15224451, compound

Procedure

Using the general method of Example 110, 3-amino-4-butylamino-2-chloroquinoline (10 g, 0.04 mole, Example 113) was reacted with 3-methoxypropionyl chloride to provide 10.3 g of the desired product as a yellow solid.

Sources & evidence

ORD record
ord-5217baf9da6245a980dcdac5a826db76
Source dataset
uspto-grants-1999_11
Patent number
US05977366

Reaction notes

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