1H-Benzotriazole-1-carboxaldehyde → HCID 54091672, compound

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Reaction Steps

To a stirred suspension of the compound of Example 30 (184 mg) in dry THF (5 mL) is added 1H-benzotriazole-1-carboxaldehyde (168 mg). The reaction mixture is heated at reflux for 48 hours, cooled and concentrated. The residue is dissolved in EtOH/CH3CN, absorbed onto silica gel and purified by flash chromatography using 7% MeOH in CH2Cl2 as the eluent to yield 155 mg of the title compound as a white solid.

Provenance & Evidence