HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tributylphosphine → 5-[4-(1-Methylindolin-2-ylmethoxy)benzyl]-3-triphenylmethylthiazolidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tributylphosphine | HCID 13831 | — |
| Reactant | 1,1'-(Azodicarbonyl)dipiperidine | HCID 73042 | — |
| Reactant | 5-(4-Hydroxybenzyl)-3-triphenylmethylthiazolidine-2,4-dione | HCID 2818126 | — |
| Reactant | 1-Methylindolin-2-ylmethanol | HCID 23298288 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 5-[4-(1-Methylindolin-2-ylmethoxy)benzyl]-3-triphenylmethylthiazolidine-2,4-dione | HCID 23298359 | 70.7% |
Reaction Steps
A procedure similar to that described in Preparation 4 was repeated, except that 2.0 g of 1-methylindolin-2-ylmethanol (prepared as described in Preparation 6), 4.73 g of 5-(4-hydroxybenzyl)-3-triphenylmethylthiazolidine-2,4-dione, 2.53 ml of tributylphosphine, 2.57 g of 1,1'-(azodicarbonyl)dipiperidine and 55 ml of benzene were used, to give 4.39 g of the title compound, melting at 62.5-65.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05977365 |
| Source dataset | uspto-grants-1999_11 |
| ORD ID | ord-238dc311895049c9a1247c01999974e7 |
| Source note | uspto-grants-1999_11 |