Dimethylformamide → methyl 1-methyl-1H-indole-2-carboxylate

Participants

Reaction Conditions

Reaction Steps

6.0 ml of methyl iodide were added dropwise to a mixture of 5.00 g of indole-2-carboxylic acid, 100 ml of dimethylformamide and 13.0 g of anhydrous potassium carbonate, and the resulting mixture was stirred at 100° C. for 6 hours. At the end of this time, the reaction mixture was worked up following the procedure described in Preparation 5, to give 5.12 g of the title compound, melting at 91.3-92.8° C.

Provenance & Evidence