Potassium Cyanide → HCID 22993564, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 80.2 g of Na2S2O5 in 250 ml of water is heated to 50° C., 50 g of 3,4-difluorobenzaldehyde are added and the reaction mixture is stirred for 1 hour at 50° C. and left to stand overnight at RT. It is cooled to 0° C., a solution of 77.7 g of KCN in 100 ml of water is added dropwise, the mixture is stirred while the temperature is allowed to rise to RT, and stirring is then continued for 1 hour at RT. The reaction mixture is extracted with ether, the organic phase is washed with water and dried over MgSO4 and the solvent is evaporated off under vacuum to give 48 g of the expected product, which is used as such.

Provenance & Evidence