HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 2-[2-[4-(2-Amino-1,3,4-oxadiazol-5-yl)-4-phenylpiperid-1-yl]ethyl]-4-benzoyl-2-(3,4-difluorophenyl)morpholine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-(2-Amino-1,3,4-oxadiazol-5-yl)-4-phenylpiperidine p-toluenesulfonate | HCID 22741723 | — |
| Reactant | 4-Benzoyl-2-(3,4-difluorophenyl)-2-[2-[4-(N',N'-dimethylureido)-4-phenylpiperid-1-yl]ethyl]morpholine hydrochloride hemihydrate | HCID 131720058 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-[2-[4-(2-Amino-1,3,4-oxadiazol-5-yl)-4-phenylpiperid-1-yl]ethyl]-4-benzoyl-2-(3,4-difluorophenyl)morpholine dihydrochloride | HCID 21200463 | 192.4% |
Reaction Steps
This compound is prepared by the procedure described in EXAMPLE 45 from 1.2 g of the compound obtained in step C of EXAMPLE 37, 1.4 g of 4-(2-amino-1,3,4-oxadiazol-5-yl)-4-phenylpiperidine p-toluenesulfonate, 1.2 g of K2CO3 and 3 ml of DMF to give 0.6 g of the expected product. M.p.=153° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05977359 |
| Source dataset | uspto-grants-1999_11 |
| ORD ID | ord-538a1385b3aa41069ca8da34f1c03212 |
| Source note | uspto-grants-1999_11 |