Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Resorcinol | HCID 5054 | — |
| Reactant | Ethyl Acetoacetate | HCID 8868 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | 4-Methylumbelliferone | HCID 5280567 | — |
Reaction Steps
To a 2 liter flask, a reaction mixture of 55 g (0.5 mole) resorcinol, 71.5 g (1.3 mole) ethyl acetoacetate, 200 g xylene, and 10 g Amberlyst 15 (Rohm and Haas) ion exchange resin catalyst was charged. With heating to a strong reflux at 110-130° C., a Von Pechman condensation reaction was carried out between resorcinol and ethyl acetoacetate to yield 7-hydroxy-4-methyl coumarine product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05980593 |
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| Source dataset | uspto-grants-1999_11 |
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| ORD ID | ord-d7f977bbbfe545a98187dcce70a1718e |
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| Source note | uspto-grants-1999_11 |
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