Pyridine → HCID 19609444, compound

Participants

Reaction Steps

To 10.8 g (0.06 mol) of 4-acetoxy-2-fluorobenzoic acid was added 60 ml of thionyl chloride, and the mixture was allowed to react under reflux for 7 hours. Then, excess thionyl chloride was distilled off, and 10 ml of pyridine and 5.3 g (0.0402 mol) of 2-octanol were added dropwise. The resultant mixture was stirred at room temperature for a whole day, and then diluted with 200 ml of ether. An organic layer was washed with dilute hydrochloric acid, with a 1N sodium hydroxide aqueous solution and with water in this order, and dried over magnesium sulfate.

Provenance & Evidence