Phenylethanolamine → HCID 86754760, compound

Participants

Reaction Steps

Synthesis of N-Allyloxycarbonyl-2-amino-1-phenylethanol (23) as illustrated in FIG. 5, reaction 4: ##STR12## Compound 23: Chemical method: 2-Amino-1-phenylethanol 15(0.50 g, 3.64 mmol) suspended in dry CH2Cl2 (20 mL) was treated with Et3N (triethylamine) (0.53 mL, 3.80 mmol) and allylchloroformate (0.41 mL, 3.86 mmol) for 30 min. The mixture was diluted with CH2Cl2 and washed with 1N KHSO4 and brine, dried (MgSO4), filtered and concentrated in vacuo. Silica gel column chromatography (eluent: CH2Cl2 /MeOH, 95/5, v/v) gave the desired product (742 mg) as a glass in 92% yield.

Provenance & Evidence