Pyridine → HCID 86754760, compound

Participants

Reaction Steps

Synthesis of N-Allyloxycarbonyl-2-amino-1-phenylethanol acetate (26) as illustrated in FIG. 5. reaction 5: ##STR14## Compound 26: Chemical method: Racemic N-allyloxycarbonyl-2-amino-1-phenylethanol 25 (51 mg, 0.23 mmol; see chemical synthesis for 23) was dissolved in dry pyridine (0.5 mL) and treated with acetic anhydride (0.33 mL, mmol). After stirring for 4 hours. at rt, the mixture was concentrated to a small volume in vacuo, dissolved in EtOAc, washed with 1N KHSO4 and brine, dried (MgSO4), filtered and concentrated in vacuo. Silica gel column chromatography (eluent: hexanes/EtOAc, 4/1, with gradient to 3/1, v/v) gave the desired product (50 mg) as an oil in 83% yield.

Provenance & Evidence