HCID 6475368, compound → HCID 474906, compound

Participants

Reaction Steps

To a suspension of 200 mg pre-hydrogenated 10% palladium/charcoal in 4 ml ethanol is added 1.2 g of [γ-hydroxy-MeLeu]4 -Ciclosporin (compound e) in 10 ml ethanol and hydrogenation is carried out at room temperature until no more hydrogen is taken up. After removal of the catalyst by filtration the solution is evaporated, yielding the title compound as an amorphous white powder, m.p. 154-156°, [α]D20 -225° (c=0.87 in CHCl3), -169° (c=0.70 in CH3OH).

Provenance & Evidence