Hydrazine hydrate (1:1) → HCID 18394513, compound

Participants

Reaction Steps

Hydrazine hydrate (56%, 18.2 ml) was added to a solution of example 17 (7.1 g) in ethanol (120 ml) and the mixture was heated at reflux for 30 min. The mixture was then cooled to RT and diluted with ethanol (300 ml), chloroform (100 ml) and water (200 ml). The layers were separated and the organic layer was dried (Na2SO4) and evaporated in vacuo. The residue was then purified by flash column chromatography, eluting with 0-10% methanol in chloroform containing 2.5% triethylamine, to give the title compound (5.39 g, 99%) as a colourless solid.

Provenance & Evidence