m-Chloroperbenzoic acid → HCID 19610326, compound

Participants

Reaction Steps

A solution of (Z)-2-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-4-methyl-3-thiomorpholinone (1.25 g, 3.6 mmol) in dichloromethane (18 ml) was cooled under nitrogen to 0° C. A solution of m-chioroperoxybenzoic acid (0.78 g, 3.6 mmol) in dichloromethane (llml) was then added dropwise over 5 minutes. The reaction mixture was stirred an additional 25 minutes and washed once with saturated sodium bicarbonate. The organic layer was dried over sodium sulfate. Rotary evaporation gave crude product which was crystallized from ethyl acetate-hexane to give desired product (1.04 g, 79%):

Provenance & Evidence