HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1602108Generated: October 25, 2026
(Triphenylphosphoranylidene)acetaldehyde → (E)-3-(5-methoxy-2-indolyl)-2-propenaldehyde
https://huagongshe.com/reaction/1602108
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | (Triphenylphosphoranylidene)acetaldehyde | HCID 75051 | — |
| Reactant | 5-Methoxy-1H-indole-2-carbaldehyde | HCID 826456 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | (E)-3-(5-methoxy-2-indolyl)-2-propenaldehyde | HCID 19610401 | 26.3% |
Reaction Steps
5-Methoxyindole-2-carboxaldehyde (1.5 g, 8.5 mmol) was dissolved in dry toluene (30 ml) and treated with (formylmethylene)triphenylphosphorane (3 g, 9.8 mmol). The reaction mixture was stirred at 85° C. for 5 h, allowed to cool and chromatographed over silica gel using hexane/EtOAc (7:3). Evaporation of the solvent yielded 0.45 g (26 %) of (E)-3-(5-methoxy-2-indolyl)-2-propenaldehyde, m.p.=145-147° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05981525 |
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| Source dataset | uspto-grants-1999_11 |
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| ORD ID | ord-73d513385919411a8ac8170bcc619bbe |
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| Source note | uspto-grants-1999_11 |
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