Morpholine → 1,3-Di-cyclopropylmethyl-8-morpholino Xanthine

HRID 1602145Notes

Reaction equation

HRID 1602145 reaction equation
[CH:1]1([CH2:4][N:5]2[C:14](=[O:15])[C:13]3[NH:12][C:11](Cl)=[N:10][C:9]=3[N:8]([CH2:17][CH:18]3[CH2:20][CH2:19]3)[C:6]2=[O:7])[CH2:3][CH2:2]1.[NH:21]1[CH2:26][CH2:25][O:24][CH2:23][CH2:22]1>>[CH:1]1([CH2:4][N:5]2[C:14](=[O:15])[C:13]3[NH:12][C:11]([N:21]4[CH2:26][CH2:25][O:24][CH2:23][CH2:22]4)=[N:10][C:9]=3[N:8]([CH2:17][CH:18]3[CH2:20][CH2:19]3)[C:6]2=[O:7])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 98146571,3-Di-cyclopropylmethyl-8-chloroxanthine

Product 1

HCID 99461491,3-Di-cyclopropylmethyl-8-morpholino Xanthine

Procedure

1,3-Di-cyclopropylmethyl-8-morpholino xanthine was prepared from 1,3-di-cyclopropylmethyl-8-chloro-xanthine (0.3 g, 0.001 mol) and morpholine (0.2 g, 0.0022 mol) using an analogous procedure to that described in Example 19. The title product was obtained as a crystalline solid, m.pt. >250° C., yield 0.09 g (26%).

Sources & evidence

ORD record
ord-ee9195d50044466ca96bc96c4aab08d5
Source dataset
uspto-grants-1999_11
Patent number
US05981535

Reaction notes

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