HCID 19610831, compound → HCID 19610859, compound

HRID 1602208Notes

Reaction equation

HRID 1602208 reaction equation
[Cl:1][C:2]1[C:3]([NH:8][C:9]2[C:10](=[O:21])[C:11]3[C:16]([C:17](=[O:20])[C:18]=2Cl)=[CH:15][CH:14]=[CH:13][CH:12]=3)=[N:4][CH:5]=[CH:6][CH:7]=1>OCC(CO)O>[Cl:1][C:2]1[C:3]2[N:4]([C:18]3[C:17](=[O:20])[C:16]4[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=4[C:10](=[O:21])[C:9]=3[N:8]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 19610831HCID 19610831, compound

Product 1

HCID 19610859HCID 19610859, compoundYield 40%

Reagents, catalysts & solvents 1

HCID 753GlycerolSolvent

Procedure

850 mg (2.66 mmol) of 2-(3-chloro-2-pyridylamino)-3-chloro-1,4-dihydro-1,4-dioxonaphthalene in solution in 80 mL of glycerol is brought to 190° C. for 20 min. After complete cooling, the yellow precipitate obtained is filtered on fritted glass, washed w-th distilled water, and recrystallized in methanol after decoloration with animal black to produce 300 mg of 4-chloro-6,11-dihydro-6,11-dioxo-naptho[2',3':4,5]imidazo[1,2-a]pyridine in the form of yellow crystals.

Workup

  1. customAfter complete cooling, the yellow precipitate obtained
  2. filtrationis filtered on fritted glass
  3. washwashed w-th
  4. distillationdistilled water
  5. customrecrystallized in methanol after decoloration with animal black

Sources & evidence

ORD record
ord-fdf591317ce34fb1911ba74083ce821f
Source dataset
uspto-grants-1999_11
Patent number
US05981544

Reaction notes

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