HCID 178425524, compound → HCID 178425525, compound

Participants

Reaction Conditions

Reaction Steps

1.3 g of 3-(3-chloro-phenylamino)-4-(3-methyl-phenylamino)-1H-pyrazolo[3,4-d]-pyrimidine (see Example 5) are dissolved in 70 ml of ethanol and at room temperature 2 ml of a 4N solution of hydrogen chloride in ethanol are added thereto. After approximately 10 minutes' stirring, the HCl salt begins to crystallize out. The solution is cooled to 0° C. and the salt is crystallized out completely by the addition of ethyl ether, yielding colorless crystals of 3-(3-chloro-phenylamino)-4-(3-methyl-phenylamino)-1H-pyrazolo[3,4-d]pyrimidine hydrochloride; m.p. 260-263° C.

Provenance & Evidence