HCID 178510815, compound → Ammonia

HRID 1602222Notes

Reaction equation

HRID 1602222 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[CH:5]=[C:6]([NH:10][C:11]2[N:16]=[CH:15][N:14]=[C:13]3[NH:17][N:18]=[C:19]([NH:20][C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[C:12]=23)[CH:7]=[CH:8][CH:9]=1>[Ni].CO>[C:2]([CH2:3][C:4]1[CH:5]=[C:6]([NH:10][C:11]2[N:16]=[CH:15][N:14]=[C:13]3[NH:17][N:18]=[C:19]([NH:20][C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[C:12]=23)[CH:7]=[CH:8][CH:9]=1)#[N:1].[NH3:1]

Participants

5

Reactant 1

HCID 178510815HCID 178510815, compound

Product 2

HCID 222AmmoniaHCID 178510814HCID 178510814, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

There is obtained from 4-(3-cyanomethyl-phenylamino)-3-phenylamino-1H-pyrazolo[3,4-d]pyrimidine (see Example 8), by reduction with Raney nickel in a solution of ammonia in methanol, 4-(3-[2-amino-ethyl]-phenylamino)-3-phenylamino-1H-pyrazolo[3,4-d]pyrimidine.

Sources & evidence

ORD record
ord-161a88f3f6064569afa2f829e4b13137
Source dataset
uspto-grants-1999_11
Patent number
US05981533

Reaction notes

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