Methanol → HCID 19610621, compound

Participants

Reaction Conditions

Reaction Steps

Preferably, the same compound is obtained as follows: To 70 mg (0.177 mmol) of 3-(3-carboxy-benzyl-amino)-4-(3-chloro-phenylamino)-1H-pyrazolo[3,4-d]pyrimidine (cf. Example 21) and 2 ml of methanol are added 0.1 ml of thionylchloride. The mixture is stirred in a sealed vessel for 3 h at 70° C., and then cooled to room temperature. Filtration and washing with methanol affords 4-(3-chloro-phenylamino)-3-(3-methoxycarbonyl-benzylamino)-1H-pyrazolo[3,4-d]pyrimidine-hydrochloride; (C20H17N6ClO2 ×HCl×0.28H2O), calc. C 53.34, H 4.15, N 18.66, Cl 15.74, H2O 1.12, found C 53.35, H 4.13, N 18.82, Cl 15.87, H2O 1.12.

Provenance & Evidence