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Acetic Acid → 3-(3-Chloro-4-methoxy-benzylamino)-4-(3-chloro-phenylamino)-1H-pyrazolo[3,4-d]pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | 3-Chloro-4-methoxybenzaldehyde | HCID 78619 | — |
| 反応物 | Sodium cyanoborohydride | HCID 5003444 | — |
| 反応物 | HCID 178509242 | HCID 178509242 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | 1,3-Dimethyl-2-imidazolidinone | HCID 6661 | — |
| 生成物 | 3-(3-Chloro-4-methoxy-benzylamino)-4-(3-chloro-phenylamino)-1H-pyrazolo[3,4-d]pyrimidine | HCID 19610550 | — |
反応手順
Analogously to Example 21, 1.00 mmol of 3-amino-4-(3-chloro-phenylamino)-1H-pyrazolo[3,4-d]pyrimidine in 26 ml of methanol, 13 ml of DMEU and 3.0 mmol of acetic acid are first reacted with 3-chloro-4-methoxy-benzaldehyde and then reduced with 7.00 mmol of NaCNBH3 (5-7 days). 3-(3-Chloro-4-methoxy-benzylamino)-4-(3-chloro-phenylamino)-1H-pyrazolo[3,4-d]pyrimidine is obtained; m.p. 205-208° C.; HPLC: TRet (Grad20-100)=12.2.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05981533 |
| 出典データセット | uspto-grants-1999_11 |
| ORD ID | ord-9803bff3c783425c808218ddbf3b0f95 |
| 出典メモ | uspto-grants-1999_11 |