Dimethylformamide diethylacetal → HCID 178489160, compound

Participants

Reaction Conditions

Reaction Steps

Under a N2 atmosphere, a suspension of 1.87 g (8.16 mmol) of 5-amino-3-(4-methoxy-phenyl)-1H-pyrazole-4-carbonitrile (for preparation see: J. Heterocyclic Chem. 27, 647 (1990)) in 33 ml of toluene is boiled under reflux for 3.5 hours with 1.64 ml of N,N-dimethylformamide diethyl acetal (95%; 9.1 mmol). Crystallization by cooling to 0° C., filtering with suction and washing with hexane yield N'-[3-(4-methoxy-phenyl)-4-cyano-1H-pyrazol-5-yl]-N,N-dimethylformamidine; m.p. 169-171° C.; TLC: Rf =0.18 (ethyl acetate:hexane=1:1); MS: (M)+ =269.

Provenance & Evidence